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Long-Term Graft Function after Allogeneic Islet Transplantation.

Jonathan R T Lakey1,2, Tatsuya Kin1, Garth L Warnock3

  • 1Clinical Islet Transplant Program, University of Alberta and Capital Health Authority, Edmonton, Alberta, Canada.

Cell Transplantation
|September 1, 2017
PubMed
Summary
This summary is machine-generated.

Islet transplantation shows promise for type 1 diabetes. One patient achieved sustained insulin secretion for 13 years post-transplant, offering hope for long-term islet graft function.

Keywords:
ImmunosuppressionIslet transplantationLong-term functionSimultaneous islet–kidney transplantationType 1 diabetes

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Area of Science:

  • Endocrinology
  • Transplantation Immunology

Background:

  • Type 1 diabetes mellitus (T1DM) management remains challenging.
  • Islet transplantation is an emerging therapeutic option for T1DM.
  • Simultaneous islet-kidney transplantation addresses both glycemic control and end-organ damage.

Purpose of the Study:

  • To evaluate the long-term efficacy of simultaneous islet-kidney transplantation in uremic T1DM patients.
  • To assess persistent islet graft function and clinical outcomes over an extended follow-up period.

Main Methods:

  • Six uremic T1DM patients received simultaneous islet-kidney transplants between 1989-1995.
  • Immunosuppression utilized steroids and cyclosporine.
  • Transplanted islets included both fresh and cryopreserved preparations, administered via portal vein infusion.

Main Results:

  • One patient demonstrated sustained insulin secretion and near-normal HbA1c for 13 years post-transplant.
  • Another patient achieved reasonable glycemic control for up to 6 years, with minimal clinical benefit at 10 years.
  • Graft function varied significantly between recipients.

Conclusions:

  • Long-term islet graft function is achievable in select T1DM patients following simultaneous transplantation.
  • Cryopreserved islet preparations can contribute to successful long-term outcomes.
  • Further research is warranted to optimize islet transplant protocols for improved patient outcomes.