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Early Intervention with Infliximab Prevents Reoperation in Crohn's Disease: A Single-Center Retrospective Analysis

Manabu Ishii1, Ken-Ichi Tarumi, Akiko Shiotani

  • 1Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, Okayama, Japan.

Digestion
|September 1, 2017
PubMed

Insights

Crohn

Area of Science:

  • Gastroenterology and immunology research.

Background:

  • Crohn's disease (CD) often necessitates multiple surgeries.
  • Identifying prognostic factors for surgery prevention is crucial.

Purpose of the Study:

  • To evaluate prognostic factors for preventing first and second surgeries in Crohn's disease patients.
  • To analyze factors influencing bowel resection and reoperation rates.

Main Methods:

  • Retrospective analysis of 115 Crohn's disease patient records (1987-2012).
  • Kaplan-Meier method for cumulative surgery rates; log-rank test and univariate/multivariate analyses for factor influence.

Main Results:

  • Ileocolitis-type CD and smoking significantly increased first surgery rates.
  • Ileocolitis-type CD and lack of early infliximab intervention increased reoperation rates.

Conclusions:

  • Ileocolitis-type CD and smoking are potential initial bowel resection factors.
  • Early infliximab intervention may prevent Crohn's disease reoperation.
Abstract

Keywords:
Early intervention with infliximabInitiating factors of bowel resectionPrevent reoperation of Crohn’s diseaseSmoking habit

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