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Updated: Feb 23, 2026

Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
Molecular Variations in Histologic Subtypes of Basal Cell Carcinoma
Min Deng1, Amanda F Marsch2, Vesna Petronic-Rosic3
1Section of Dermatology, The University of Chicago Pritzker School of Medicine, Chicago, IL.
Abstract:
There are many molecular variations in the histologic subtypes of basal cell carcinoma (BCC); Ki67 and Bcl-2 expression differs among them and might relate to their prognostic features. The clinically notable friability and its histologic counterpart, retraction, are dependent on cell-cell adhesion and basement membrane characteristics, which may be altered in different ways depending on the tumor morphology and phenotype. Finally, we discuss the pathogenesis of BCCs and recent molecular advances with a review of new and upcoming molecular-based therapeutics.
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