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The process of source transformation in the frequency domain entails the conversion of a voltage source, positioned in series with an impedance, into a current source that is parallel to an impedance, or the other way around. It is essential to maintain the following relationships while transitioning from one source type to another.
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Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
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Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
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Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role in speciation by changing genome sizes and modifying gene expression patterns. For example, in bacteria, transposition can lead to conferring antibiotic resistance. Movement of transposable elements within the genetic pool of pathogenic bacteria can aid in transfer of antibiotic-resistant genetic elements. In eukaryotes, transposons can carry out...
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Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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Related Experiment Video

Updated: Feb 23, 2026

Gene Digital Circuits Based on CRISPR-Cas Systems and Anti-CRISPR Proteins
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Gene Digital Circuits Based on CRISPR-Cas Systems and Anti-CRISPR Proteins

Published on: October 18, 2022

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How transcription circuits explore alternative architectures while maintaining overall circuit output.

Chiraj K Dalal1, Alexander D Johnson1,2

  • 1Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, California 94158, USA.

Genes & Development
|September 2, 2017
PubMed
Summary

Gene regulatory networks evolve, but gene expression patterns remain stable. This review explores how transcription regulators and cis-regulatory sequences adapt while maintaining consistent gene expression across species.

Keywords:
evolutiongene regulationtranscription

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Area of Science:

  • Evolutionary biology
  • Genetics
  • Systems biology

Background:

  • Transcription regulators control gene expression by binding to cis-regulatory sequences.
  • While genes and regulators are conserved, their connections (regulatory circuits) extensively rewire over evolutionary time.

Purpose of the Study:

  • To review evidence for the preservation of gene expression patterns despite evolutionary rewiring of transcription circuits.
  • To explore computational models that elucidate mechanisms of this preservation.

Main Methods:

  • Review of case studies demonstrating conserved gene expression patterns.
  • Analysis of in silico models of transcription circuit evolution.

Main Results:

  • Extensive evolutionary rewiring of transcription factor binding sites and gene targets occurs.
  • Despite rewiring, resulting gene expression patterns are often preserved across species.

Conclusions:

  • Preservation of gene expression patterns is a common feature in the evolution of transcription regulatory circuits.
  • This suggests functional constraints maintain expression despite changes in underlying DNA sequences.