Optimal achieved blood pressure for patients with stable coronary artery disease

Area of Science:

• Cardiology
• Hypertension Research
• Public Health

Background:

• Stable coronary artery disease (CAD) management requires optimal blood pressure (BP) control.
• Previous studies on ideal BP targets primarily focus on Western populations.
• Ethnic variations may influence the relationship between BP and cardiovascular outcomes.

Purpose of the Study:

• To determine the ideal achieved blood pressure (BP) targets for ethnic Chinese patients with stable coronary artery disease (CAD).
• To investigate the association between different BP levels and cardiovascular events in this specific cohort.
• To provide evidence-based BP recommendations for non-Western populations with stable CAD.

Main Methods:

• A prospective study involving 2,045 ethnic Chinese patients with stable CAD who underwent percutaneous coronary interventions.
• Collected demographic data, achieved systolic blood pressure (SBP), and diastolic blood pressure (DBP) at baseline.
• Monitored total cardiovascular events over 12 and 24 months, analyzing risks associated with different BP ranges.

Main Results:

• Patients with systolic BP <120 mmHg and ≥160 mmHg showed increased cardiovascular event risk compared to SBP 120-139 mmHg at both 12 and 24 months.
• Low diastolic BP (<70 mmHg) was also associated with increased cardiovascular event risk compared to DBP 70-79 mmHg at 24 months.
• Achieved SBP averaged 130.6 ± 17.7 mmHg and DBP averaged 74.9 ± 12.0 mmHg.

Conclusions:

• Systolic BP levels below 120 mmHg or above 160 mmHg, and diastolic BP below 70 mmHg, are linked to higher cardiovascular event rates in ethnic Chinese patients with stable CAD.
• These findings suggest that current BP management guidelines may need adjustment for non-Western populations.
• Establishing optimal BP targets is essential for improving cardiovascular outcomes in diverse CAD patient groups.