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Beta-blockade reverses regional dysfunction in ischemic myocardium.

B J Leone, J J Lehot, C M Francis

    Anesthesia and Analgesia
    |July 1, 1987
    PubMed
    Summary
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    Oxprenolol beta-blockade protects the heart muscle during critical artery constriction against halothane effects. This beta-blocker minimized damage and reduced adverse cardiac responses in dogs.

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Myocardial compromise due to critical coronary artery constriction poses risks during anesthesia.
    • Halothane, a common anesthetic, can adversely affect cardiac function, especially in compromised hearts.

    Purpose of the Study:

    • To investigate the protective effects of oxprenolol-induced beta-blockade.
    • To assess protection against high halothane concentrations in a canine model of critical left anterior descending coronary artery constriction.

    Main Methods:

    • Obtained halothane dose-response curves in six dogs across three phases: control, critical constriction, and critical constriction with oxprenolol.
    • Administered 0.3 mg/kg intravenous oxprenolol during the third phase.

    Main Results:

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  • Ventricular function depression was similar across phases.
  • At 2.0% inspired halothane, oxprenolol significantly minimized systolic shortening depression in the compromised segment (10.2% +/- 1.8 vs. 6.5% +/- 1.4, P < 0.05).
  • Oxprenolol abolished the increase in postsystolic shortening observed during critical constriction.

    • Conclusions:

    • Oxprenolol demonstrates a protective effect on regional myocardial function during critical coronary constriction.
    • Potential mechanisms include effects on myocardial metabolism or endocardial blood flow.