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Updated: Feb 23, 2026
Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
Published on: December 13, 2018
Cytotoxicity induced by carbon nanotubes in experimental malignant glioma
Samuel Romano-Feinholz1, Alelí Salazar-Ramiro2, Emilio Muñoz-Sandoval3
1Division of Neurosurgery.
Abstract:
Despite multiple advances in the diagnosis of brain tumors, there is no effective treatment for glioblastoma. Multiwalled carbon nanotubes (MWCNTs), which were previously used as a diagnostic and drug delivery tool, have now been explored as a possible therapy against neoplasms. However, although the toxicity profile of nanotubes is dependent on the physicochemical characteristics of specific particles, there are no studies exploring how the effectivity of the carbon nanotubes (CNTs) is affected by different methods of production. In this study, we characterize the structure and biocompatibility of four different types of MWCNTs in rat astrocytes and in RG2 glioma cells as well as the induction of cell lysis and possible additive effect of the combination of MWCNTs with temozolomide. We used undoped MWCNTs (labeled simply as MWCNTs) and nitrogen-doped MWCNTs (labeled as N-MWCNTs). The average diameter of both pristine MWCNTs and pristine N-MWCNTs was ~22 and ~35 nm, respectively. In vitro and in vivo results suggested that these CNTs can be used as adjuvant therapy along with the standard treatment to increase the survival of rats implanted with malignant glioma.
Insights
This study explores multiwalled carbon nanotubes (MWCNTs) as a novel therapy for glioblastoma. Results show MWCNTs, combined with standard treatment, can enhance survival in malignant glioma models.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Glioblastoma remains an incurable brain tumor despite diagnostic advances.
- Multiwalled carbon nanotubes (MWCNTs) show promise as a therapeutic agent against neoplasms.
- The impact of MWCNT production methods on therapeutic efficacy requires further investigation.
Purpose of the Study:
- To characterize the structure and biocompatibility of four MWCNT types.
- To evaluate MWCNT-induced cell lysis in rat astrocytes and RG2 glioma cells.
- To assess the additive therapeutic effect of MWCNTs combined with temozolomide.
Main Methods:
- Characterization of undoped and nitrogen-doped MWCNTs (N-MWCNTs) with varying diameters (~22 nm and ~35 nm).
- In vitro studies using rat astrocytes and RG2 glioma cells.
- In vivo studies involving rats implanted with malignant glioma.
Main Results:
- MWCNTs demonstrated biocompatibility and induced cell lysis in glioma cells.
- Nitrogen-doped MWCNTs exhibited distinct structural and biological properties.
- Combination therapy of MWCNTs with temozolomide showed an additive effect.
Conclusions:
- MWCNTs hold potential as an adjuvant therapy for glioblastoma.
- Production methods influence MWCNT characteristics and therapeutic potential.
- Further research into MWCNT-based therapies could improve glioblastoma treatment outcomes.
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