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Related Concept Videos

Pain01:20

Pain

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Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
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Analgesia and Pain Management01:25

Analgesia and Pain Management

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Nociception01:44

Nociception

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Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
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Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
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Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

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Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
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Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Related Experiment Video

Updated: Feb 23, 2026

Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram
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Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram

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Pain as a disease: an overview.

William Raffaeli1, Elisa Arnaudo1

  • 1Fondazione ISAL Institute for Research on Pain, Torre Pedrera, Rimini, Italy.

Journal of Pain Research
|September 2, 2017
PubMed
Summary

Pain is often debated as a disease, despite its significant global burden. Recognizing pain as a distinct pathologic condition is vital for awareness and developing new treatments.

Area of Science:

  • Pain research
  • Pathology
  • Global health

Background:

  • The concept of pain as a distinct pathologic entity is debated.
  • Despite evidence of its burden, pain lacks ultimate recognition as a disease.
  • Current understanding necessitates a clearer definition for effective management.

Purpose of the Study:

  • To analyze the notion of pain as a disease.
  • To provide a historical overview of pain conceptualizations.
  • To present evidence supporting pain as a distinct pathologic state.

Main Methods:

  • Historical analysis of pain concepts.
  • Review of evidence supporting pain as a disease.
  • Conceptual analysis of pain's pathologic nature.
Keywords:
chronic painclassificationdiseasepain

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Main Results:

  • Pain's conceptualization has evolved historically.
  • Substantial evidence supports viewing pain as a disease.
  • A clear definition of pain as a disease is currently lacking.

Conclusions:

  • Recognizing pain as a definite pathologic state is crucial.
  • This recognition can raise awareness of pain as a neglected global health problem.
  • It will promote the development of novel, specific therapeutic strategies.