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Related Experiment Video

Updated: Feb 23, 2026

Author Spotlight: Insights into Visual Cortex Research Through Wide-View fMRI Mapping

Author Spotlight: Insights into Visual Cortex Research Through Wide-View fMRI Mapping

Published on: December 8, 2023

Visual Dysfunction in Posterior Cortical Atrophy.

Mari N Maia da Silva^1,2, Rebecca S Millington³, Holly Bridge³

¹The National Hospital for Neurology and Neurosurgery, London, United Kingdom.

Frontiers in Neurology

|September 2, 2017

Summary

This summary is machine-generated.

Posterior cortical atrophy (PCA) is a neurodegenerative syndrome affecting vision and cognition. This review details its concept evolution, diagnostic criteria, and visual deficits, often linked to Alzheimer pathology.

Keywords:

Alzheimer’s disease (AD)Balint’s syndrome hemianopia magnetic resonance imaging imaging posterior cortical atrophy visual agnosia visual fields

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Area of Science:

Neuroscience
Neurology
Ophthalmology

Background:

Posterior cortical atrophy (PCA) is a clinical syndrome characterized by progressive cortical visual dysfunction.
Imaging reveals degeneration in the occipital, parietal, and posterior temporal lobes.
Alzheimer pathology is the most common underlying cause of PCA.

Purpose of the Study:

To review the historical development of the concept of posterior cortical atrophy.
To critically discuss evolving diagnostic criteria and differential diagnoses.
To highlight visual dysfunctions and their neural correlates in PCA.

Main Methods:

Literature review summarizing the evolution of PCA concept and diagnosis.
Discussion of visual deficits, including simultanagnosia, visual agnosia, and visual field defects.
Review of neuroimaging findings and their role in differential diagnosis.

Main Results:

PCA diagnosis has evolved significantly since its introduction.
Visual impairments are central to PCA, with classical and newly recognized deficits.
Neuroimaging plays a crucial role in differentiating PCA from related conditions.

Conclusions:

Understanding PCA's concept and diagnostic evolution is essential.
Accurate diagnosis relies on recognizing specific visual dysfunctions and neuroimaging patterns.
Further research can refine diagnostic criteria and treatment strategies for PCA.