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A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
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Protein-Protein Interactions in Virus-Host Systems.

Anderson F Brito1, John W Pinney1

  • 1Department of Life Sciences, Centre for Integrative Systems Biology and Bioinformatics, Imperial College LondonLondon, United Kingdom.

Frontiers in Microbiology
|September 2, 2017
PubMed
Summary

Understanding virus-host protein interactions is key for antiviral therapies. This review covers viral and host protein evolution, interactions, and data sources for studying these crucial relationships.

Keywords:
PPIdatabasesintegrative biologymolecular evolutionprotein interaction networksstructural biologyviral evolutionvirus-host interactions

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Area of Science:

  • Virology
  • Structural Biology
  • Evolutionary Biology

Background:

  • Virus-host protein interactions are central to viral infections and antiviral therapy development.
  • Understanding protein architectures, evolutionary mechanisms, and data sources is essential for studying these interactions.

Purpose of the Study:

  • To provide a comprehensive overview of virus-host protein interactions.
  • To discuss viral domain repertoires, their evolution, and roles in infection.
  • To explore protein interaction networks (PINs) and their evolutionary dynamics.

Main Methods:

  • Review of existing literature on protein-protein interactions (PPIs).
  • Analysis of viral and host protein domain evolution and interaction modes.
  • Discussion of protein interaction network (PIN) representation and analysis.
  • Overview of experimental PPI approaches and biomolecular data sources.

Main Results:

  • Viral proteins often interact with central, highly connected host proteins.
  • Protein interfaces evolve through mutations, rewiring, gene duplication, HGT, and mimicry.
  • "Party hubs" (stable interactions) evolve slower than "date hubs" (transient interactions).
  • Blocking virus-host PPIs is a primary mechanism for antiviral therapies.

Conclusions:

  • Studying virus-host protein interactions requires integrating knowledge of protein architecture, evolution, and data resources.
  • Evolutionary dynamics of viral and host proteins drive infection mechanisms and therapeutic targets.
  • A deep understanding of PPIs is critical for developing effective antiviral strategies.