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Updated: Aug 12, 2026

Human Internal Mammary Artery (IMA) Transplantation and Stenting: A Human Model to Study the Development of In-Stent Restenosis
Published on: May 9, 2012
Anatomical studies to support the expanded use of the internal mammary artery graft for myocardial revascularization
The internal mammary artery pedicle graft is frequently used for coronary bypass. Five internal mammary artery pedicle grafts, harvested but not utilized for coronary bypass, underwent histological examination. The histological studies demonstrated that the vasa vasorum were confined to the adventitia and did not penetrate the media of the internal mammary artery. These observations indicate that the media is nourished entirely from the lumen and suggest that harvesting the internal mammary artery as a free graft would not subject the wall of the artery to ischemic injury. Subsequent to these studies, we used the right internal mammary artery as a free graft to revascularize the distal circumflex coronary artery in 12 patients. The free graft was anastomosed to marginal branches of the circumflex and was then brought up to the left internal mammary artery pedicle graft and anastomosed end-to-side. This procedure has not resulted in excessive postoperative bleeding or sternal infections, and has relieved the anginal syndrome in all 12 patients.
The internal mammary artery pedicle graft is frequently used for coronary bypass. Five internal mammary artery pedicle grafts, harvested but not utilized for coronary bypass, underwent histological examination. The histological studies demonstrated that the vasa vasorum were confined to the adventitia and did not penetrate the media of the internal mammary artery. These observations indicate that the media is nourished entirely from the lumen and suggest that harvesting the internal mammary artery as a free graft would not subject the wall of the artery to ischemic injury. Subsequent to these studies, we used the right internal mammary artery as a free graft to revascularize the distal circumflex coronary artery in 12 patients. The free graft was anastomosed to marginal branches of the circumflex and was then brought up to the left internal mammary artery pedicle graft and anastomosed end-to-side. This procedure has not resulted in excessive postoperative bleeding or sternal infections, and has relieved the anginal syndrome in all 12 patients.
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