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Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

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Spatio-temporal source cluster analysis reveals fronto-temporal auditory change processing differences within a

Talitha C Ford¹, Will Woods², David P Crewther¹

¹Centre for Human Psychopharmacology, Faculty of Health, Arts and Design, Swinburne University of Technology, Melbourne, Victoria, Australia.

Neuroimage. Clinical

|September 2, 2017

Summary

Individuals with higher social disorganisation (SD) show reduced right hemisphere auditory processing. This indicates that fronto-temporal auditory deficits may link to psychosocial functioning in the subclinical population.

Keywords:

Autism MNE Magnetoencephalography Mismatch field Mismatch negativity Schizotypy Social Disorganisation

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Area of Science:

Neuroscience
Psychiatry
Auditory Neuroscience

Background:

Social disorganisation (SD) is a shared phenotype in autistic and schizotypal spectrum disorders.
Auditory processing deficits, specifically mismatch negativity/field (MMN/F), are observed in these conditions.
SD is present in the subclinical population, suggesting potential underlying neural differences.

Purpose of the Study:

To investigate differences in MMN/F cortical spatio-temporal source activity between high and low SD groups.
To explore the relationship between SD severity and auditory processing in subclinical adults.
To identify neural correlates of psychosocial functioning related to auditory processing.

Main Methods:

Magnetoencephalography (MEG) was used to record brain activity.
Participants underwent an MMF paradigm with standard and deviant auditory tones.
Spatio-temporal source cluster analysis with permutation testing was applied to MMN/F data.

Main Results:

No significant differences in cortical activation to standard tones were found between groups.
The high SD group exhibited significantly reduced right hemisphere fronto-temporal and insular cortex activation to deviant tones (p=0.038).
The mismatch negativity (MMN) itself did not differ significantly between the high and low SD groups.

Conclusions:

Individuals with higher levels of the social disorganisation phenotype show impaired right fronto-temporal processing of auditory changes.
These findings suggest a deficit in right fronto-temporal auditory processing associated with psychosocial functioning.
This highlights the potential role of specific neural pathways in mediating social and auditory processing in subclinical populations.