Effects of H-2 antagonists on the elimination of bupivacaine

The effects of two histamine H-2 antagonists, cimetidine and ranitidine, on the elimination of bupivacaine were studied in four male volunteers. The cimetidine-treated group demonstrated a statistically significant decrease in clearance of bupivacaine. These results indicate that concomitant administration of cimetidine and bupivacaine may increase the likelihood of toxicity of the latter agent.