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Area of Science:

  • Microfluidics
  • Biophysics
  • Particle Separation

Background:

  • Deterministic Lateral Displacement (DLD) arrays are crucial for high-resolution size-based separation of microparticles and bioparticles.
  • Accurate DLD operation relies on maintaining a fixed flow angle relative to the obstacle array.
  • Anisotropic permeability, an intrinsic property of microfluidic arrays, can disrupt optimal device function.

Purpose of the Study:

  • To investigate and demonstrate anisotropic permeability in microfluidic DLD arrays.
  • To elucidate the impact of array design features on flow behavior and separation accuracy.
  • To provide design recommendations for optimizing DLD performance.

Main Methods:

  • Experimental validation of flow behavior within DLD arrays.
  • Computational modeling using lattice-Boltzmann simulations to analyze fluid dynamics.
  • Systematic evaluation of different array geometries and post shapes.

Main Results:

  • Subtle variations in array design, specifically unequal axial/lateral gaps and asymmetric post shapes, induce anisotropic permeability.
  • Anisotropic permeability generates lateral pressure gradients, causing flow inclination and altering the critical separation size.
  • The rotated-square array layout exhibits no intrinsic anisotropy, unlike the parallelogram layout.

Conclusions:

  • Anisotropic permeability in DLD arrays can lead to unpredictable particle trajectories and device failure for intended separation tasks.
  • The rotated-square array layout is recommended over the parallelogram layout to avoid inherent anisotropy.
  • Guidelines are provided to mitigate the adverse effects of anisotropy on DLD performance.