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Insights of Chinese medicine on ventricular remodeling: Multiple-targets, individualized-treatment

Dan-Cai Fan1, Jian-Yong Qi1, Min-Zhou Zhang2

  • 1AMI Key Laboratory of Chinese Medicine in Guangzhou, Intensive Care Research Team of Traditional Chinese Medicine, Guangdong Province Hospital of Chinese Medicine, 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Science, Guangzhou, 510006, China.

Chinese Journal of Integrative Medicine
|September 2, 2017
PubMed

Insights

Ventricular remodeling (VR) is a major cause of heart failure, and current treatments are insufficient. This review explores how Chinese medicine (CM) can effectively treat VR by examining its mechanisms and therapeutic applications.

Area of Science:

  • Cardiology
  • Integrative Medicine
  • Pharmacology

Background:

  • Ventricular remodeling (VR) is a pathological cardiac process following myocardial injury, leading to heart failure.
  • Existing therapies for VR are often ineffective, costly, and associated with adverse effects or resistance.
  • Chinese medicine (CM) has a long history of use in treating cardiovascular diseases.

Purpose of the Study:

  • To review the current understanding of VR mechanisms.
  • To explore the molecular and functional effects of CM on VR.
  • To elucidate the therapeutic mechanisms of CM in treating VR.

Main Methods:

  • Systematic review of published literature on VR and CM.
  • Analysis of mechanistic studies on VR.
  • Evaluation of molecular biology and myocardial functional studies of CM therapies.
  • Investigation into the mechanisms of CM action on VR.

Main Results:

  • VR is a complex process driven by myocardial injury, resulting in cardiac dysfunction.
  • CM therapies demonstrate potential in modulating molecular pathways and improving myocardial function in VR.
  • Specific CMs and their active compounds show promise in targeting VR mechanisms.

Conclusions:

  • CM offers a promising avenue for novel therapeutic strategies against VR.
  • Further research into CM mechanisms can lead to more effective treatments for heart failure.
  • Integrating CM into cardiac care may improve patient outcomes for VR.

Keywords:
Chinese medicineheart failureventricular remodeling

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