Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Leptomeningeal disease (LMD) after resection of brain metastases: results of the multicenter SUBAROMA study.

Journal of neuro-oncology·2026

Same author

Assessment of Response to Regorafenib in Patients with Glioma Relapse Using <sup>18</sup>F-FET PET and MRI.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026

Same author

Assessment of <sup>18</sup>F-FET PET-based response in patients with gliomas using the PET RANO 1.0 criteria.

Neuro-oncology advances·2025

Same author

Concurrent and adjuvant temozolomide for 1p/19q non-co-deleted anaplastic glioma (CATNON; EORTC study 26053-22054): final and exploratory analyses of a randomised, open-label, phase 3 trial.

The Lancet. Oncology·2025

Same author

O-(2-[<sup>18</sup>F]fluoroethyl)-L-tyrosine-PET-guided versus contrast-enhanced T1-weighted MRI-guided re-irradiation in patients with recurrent glioblastoma (GLIAA/NOA-10 ARO2013-01): a multicentre, open-label, randomised trial.

The Lancet. Oncology·2025

Same author

Clinical potential of [<sup>18</sup>F]FET PET in patients with circumscribed astrocytic glioma.

European journal of nuclear medicine and molecular imaging·2025

Search research articles

Related Experiment Video

Updated: Feb 23, 2026

Translational Orthotopic Models of Glioblastoma Multiforme

Translational Orthotopic Models of Glioblastoma Multiforme

Published on: February 17, 2023

Pseudoprogression after glioma therapy: an update.

Norbert Galldiks^1,2,3, Martin Kocher⁴, Karl-Josef Langen^2,5

¹a Department of Neurology , University of Cologne , Cologne , Germany.

Expert Review of Neurotherapeutics

|September 2, 2017

Summary

Advanced neuroimaging, including perfusion-weighted imaging (PWI) MRI and amino acid PET scans, can help distinguish glioma pseudoprogression from true tumor growth. These methods offer valuable diagnostic information for brain tumor patients.

Keywords:

FET PET PWI advanced MRI checkpoint inhibitors glioblastoma immunotherapy temozolomide

More Related Videos

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma

Published on: April 16, 2019

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

Published on: October 27, 2014

Related Experiment Videos

Last Updated: Feb 23, 2026

Translational Orthotopic Models of Glioblastoma Multiforme

Translational Orthotopic Models of Glioblastoma Multiforme

Published on: February 17, 2023

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma

Published on: April 16, 2019

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

Published on: October 27, 2014

Area of Science:

Neuro-oncology
Radiology
Nuclear Medicine

Background:

Standard MRI struggles to differentiate glioma pseudoprogression from tumor progression.
Accurate diagnosis is crucial for effective treatment planning in brain tumor patients.

Purpose of the Study:

To review advanced neuroimaging techniques for identifying pseudoprogression in gliomas.
To assess the diagnostic value of PET and PWI MRI in this context.

Main Methods:

Literature search focusing on pseudoprogression, gliomas, PET, and PWI MRI.
Review of current evidence on the efficacy of these advanced imaging modalities.

Main Results:

Perfusion-weighted imaging (PWI) MRI and amino acid PET show strong potential in diagnosing pseudoprogression.
These techniques provide valuable supplementary information beyond standard MRI.

Conclusions:

PWI MRI and amino acid PET are valuable tools for overcoming diagnostic challenges in glioma pseudoprogression.
Despite availability and standardization issues, these methods offer significant benefits and warrant wider adoption.