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Updated: Feb 23, 2026
Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
Published on: May 24, 2024
High expression of Parkin predicts easier recurrence of patients with adjuvant transarterial chemoembolization
Changlie Zhang1, Zhihong Song2, Guangji Yu3
1Department of Vascular Surgery, Linyi People's Hospital, Linyi, Shandong, PR China.
Aim:
To investigate the clinical significance of E3 ubiquitin ligase Parkin in patients with adjuvant transarterial chemoembolization after curative resection of hepatocellular carcinoma.
Methods:
Parkin expression of hepatocellular carcinomas was detected and its correlation with clinicopathological factors was analyzed with χ2 test. The significance of Parkin in prognosis and recurrence was analyzed with log-rank test and the Cox-regression model.
Results:
High expression of Parkin could result in lower recurrence-free survival rate instead of overall survival rate. Larger tumor size, positive tumor recurrence, advanced T, N, M and TNM stage were significantly associated with poorer prognosis. Larger tumor size, advanced T and TNM stage could lead to higher recurrence.
Conclusion:
High Parkin expression could predict easier recurrence to patients with adjuvant transarterial chemoembolization.
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