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Hyperphosphataemia and bone resorption in histamine injected laying hens
Summary
Histamine impacts bone resorption during eggshell formation by altering calcium-45 (45Ca) and phosphorus-32 (32P) clearance. This suggests histamine influences skeletal phosphorus release, contributing to hyperphosphatemia.
Area of Science:
- Animal Physiology
- Biochemistry
- Bone Metabolism
Background:
- Eggshell formation requires significant calcium and phosphate mobilization.
- Histamine is a known mediator in physiological processes, but its role in bone metabolism during calcification is less understood.
Purpose of the Study:
- To investigate the effects of histamine on bone resorption and mineral dynamics during eggshell formation.
- To determine histamine's influence on the plasma clearance and skeletal handling of calcium and phosphate.
Main Methods:
- Administered histamine to birds during eggshell formation.
- Traced the plasma clearance and tissue distribution of injected calcium-45 (45Ca) and phosphorus-32 (32P).
- Measured plasma levels and specific activity of isotopes in bone and eggshells.
Main Results:
- Histamine decreased the plasma disappearance rates of 45Ca and 32P.
- No significant changes were observed in femur or eggshell mineral content.
- Histamine increased plasma 32P levels and decreased bone 32P specific activity.
Conclusions:
- Histamine appears to inhibit the clearance of phosphate from plasma during eggshell formation.
- The observed changes suggest histamine promotes the release of phosphate from bone, contributing to elevated plasma phosphate levels (hyperphosphatemia).