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Olfactory Dysfunction Associated With Neuro-Behçet Disease
Remzi Doğan1, Burak Ertaş, Berke Özücer
1*Department of Otorhinolaryngology, Bezmiâlem Vakif University, Medical Faculty, Fatih †Department of Otorhinolaryngology, Acibadem University, Maslak Hospital ‡Department of Otorhinolaryngology, Gaziosmanpasa Taksim Research and Education Hospital §Department of Neurology, Istanbul Medipol University, Istanbul, Turkey.
The Journal of Craniofacial Surgery
|September 2, 2017
Summary
Neuro-Behçet disease (NBD) patients experience worse olfactory dysfunction than Behçet disease (BD) patients. Neurologic involvement, particularly parenchymal, significantly worsens smell loss in NBD, correlating with disease duration.
Area of Science:
- Neurology
- Ophthalmology
- Immunology
Background:
- Behçet disease (BD) is characterized by multisystem inflammation.
- Neurologic involvement in BD defines Neuro-Behçet disease (NBD).
- Olfactory dysfunction is observed in BD, but its cause (mucosal vs. neurologic) is unclear.
Purpose of the Study:
- To determine if neurologic involvement exacerbates olfactory dysfunction in NBD.
- To investigate the relationship between neurologic disability and olfactory function in NBD patients.
Main Methods:
- Compared olfactory function (CCCRC test) and neurologic disability (EDSS) in 16 NBD patients and 16 controls.
- Utilized MRI to categorize NBD lesions as parenchymal or nonparenchymal.
- Performed correlation analysis between disease duration, EDSS scores, and olfactory function.
Main Results:
- NBD patients exhibited significantly reduced olfactory scores (mean 4.60) compared to controls (mean 6.5).
- Parenchymal NBD cases showed worse neurologic disability (EDSS 2.08) and olfactory scores (4.38) than vascular cases (EDSS 0.75, olfactory score 5.25).
- A significant correlation was found between NBD duration and both olfactory and neurologic dysfunction severity.
Conclusions:
- NBD is associated with more severe olfactory dysfunction than BD.
- Neurologic involvement, especially parenchymal, significantly contributes to olfactory impairment in NBD.
- Disease duration is a key factor in the severity of olfactory and neurologic dysfunction in NBD.
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