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Changes in Skin Color: Clinical Perspectives01:14

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Assessment of the Cardiovascular System II: Inspection01:29

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Inspection is the initial step in assessing the cardiovascular system. It involves a detailed visual examination that provides crucial information about a patient's circulatory and cardiac health. This systematic process, conducted from head to toe, helps identify signs of cardiovascular conditions by observing physical appearance, skin and mucous membranes, jugular and carotid pulsations, chest symmetry, and the condition of the extremities.
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Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
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Related Experiment Video

Updated: Feb 23, 2026

A Simplified Technique for Producing an Ischemic Wound Model
12:00

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Bruises on the ears and body.

Diana M Sarmiento1, Thomas F Northrup1, Yu Wah1

  • 1University of Texas Health Science Center at Houston, TX, USA.

The Journal of Family Practice
|September 2, 2017
PubMed
Summary
This summary is machine-generated.

A woman presented with painful bruises and deep vein thrombosis (DVT), linked to cocaine use and autoimmune markers. This case highlights the complex interplay between substance abuse and vasculitis.

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Area of Science:

  • Internal Medicine
  • Dermatology
  • Rheumatology

Background:

  • A 34-year-old woman with a history of cocaine abuse presented with recurrent painful bruises and deep vein thrombosis (DVT).
  • The patient had a 7-year history of cocaine abuse, with initial symptoms appearing after using cocaine from a new dealer.

Observation:

  • The patient sought medical care on three occasions within a month for painful bruises and DVT.
  • Skin lesions, described as bruise-like, appeared on her earlobes, face, trunk, and lower extremities.
  • Previous admissions revealed positive urine drug tests for cocaine and positive serological markers including cytoplasmic antineutrophil cytoplasmic antibodies, antinuclear antibodies, anti-double stranded DNA, and anticardiolipin IgM.

Findings:

  • Despite unremarkable initial laboratory tests on her most recent visit, prior admissions showed a complex autoimmune profile.
  • The clinical presentation and laboratory findings suggest a potential link between cocaine use and an autoimmune vasculitic process.

Implications:

  • This case underscores the importance of considering drug-induced vasculitis in patients with recurrent bruising, DVT, and positive autoimmune markers.
  • Prompt diagnosis and management, including cessation of substance abuse and appropriate immunosuppressive therapy, are crucial for patient outcomes.