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Sirtuin 1 Levels in Recurrent Implantation Failure.

Yaprak Engin-Ustun¹, A Seval Ozgu-Erdinc¹, Emel Kiyak Caglayan¹

¹Reproductive Endocrinology Department, University of Health Sciences, Dr. Zekai Tahir Burak Health Practice Research Center, Ankara, Turkey.

Revista Brasileira De Ginecologia E Obstetricia : Revista Da Federacao Brasileira Das Sociedades De Ginecologia E Obstetricia

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Summary

Serum sirtuin 1 levels were higher in women with recurrent implantation failure (RIF), though not statistically significant. Elevated sirtuin 1 may link to inflammation in RIF patients.

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Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Published on: August 4, 2021

Area of Science:

Reproductive Endocrinology
Cellular Biology
Biochemistry

Background:

Sirtuin 1 (SIRT1) plays a crucial role in cellular processes like apoptosis and stress.
Implantation failure, particularly recurrent implantation failure (RIF), is a significant challenge in assisted reproductive technologies.

Purpose of the Study:

To investigate serum sirtuin 1 levels in women diagnosed with recurrent implantation failure (RIF).

Main Methods:

A cross-sectional study involving 28 women with RIF, 29 healthy pregnant women post-IVF, and 30 women with a single IVF cycle failure.
Serum levels of nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin-1 (SIRT1) were quantified using a commercial colorimetric kit.

Main Results:

Serum sirtuin 1 levels were observed to be higher in RIF patients compared to both non-pregnant and healthy pregnant controls.
This observed difference did not achieve statistical significance, likely due to the limited sample size.
A statistically significant positive correlation was found between patient age and sirtuin 1 levels (r=0.277, p=0.009).

Conclusions:

While serum sirtuin 1 levels trend higher in RIF patients, further research with larger cohorts is needed to confirm statistical significance.
The elevated sirtuin 1 levels in RIF may be associated with underlying inflammation imbalances.
Age is a significant factor correlated with sirtuin 1 levels in this patient population.