Related Experiment Video
Updated: Feb 23, 2026
Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions
Published on: October 17, 2017
Monocyte/high-density lipoprotein ratio predicts the mortality in ischemic stroke patients
Asli Bolayir1, Seyda Figul Gokce1, Burhanettin Cigdem1
1Cumhuriyet University Neurology Department, Sivas, Turkey.
Objective:
The inflammatory process is a very important stage in the development and prognosis of acute ischemic stroke (AIS). The monocyte to high-density lipoprotein (HDL) ratio (MHR) is accepted as a novel marker for demonstrating inflammation. However, the role of MHR as a predictor of mortality in patients with AIS remains unclear.
Methods:
We retrospectively enrolled 466 patients who were referred to our clinic within the first 24hours of symptom presentation and who were diagnosed with AIS between January 2008 and June 2016. Four hundred and eight controls of similar age and gender were also included. The patient group was classified into two groups according to 30-day mortality. The groups were compared in terms of monocyte counts, HDL, and MHR values.
Results:
The patient group had significantly higher monocyte counts and lower HDL levels; therefore, this group had higher values of MHR compared to controls. Additionally, the monocyte count and MHR value were higher, and the HDL level was lower in non-surviving patients (p<0.001). The MHR value was also observed as a significant independent variable of 30-day mortality in patients with AIS (p<0.001). The optimum cut-off value of MHR in predicting the 30-day mortality for patients with AIS was 17.52 (95% CI 0.95-0.98).
Conclusion:
Our study demonstrated that a high MHR value is an independent predictor of 30-day mortality in patients with AIS.
Insights
The monocyte to HDL ratio (MHR) is a significant predictor of 30-day mortality in acute ischemic stroke (AIS) patients. Higher MHR values indicate increased inflammation and a greater risk of death following AIS.
Area of Science:
- Cardiology
- Neurology
- Inflammation Research
Background:
- Inflammation plays a crucial role in acute ischemic stroke (AIS) development and prognosis.
- The monocyte to high-density lipoprotein ratio (MHR) is recognized as a novel inflammation marker.
- The predictive value of MHR for mortality in AIS patients requires further investigation.
Purpose of the Study:
- To evaluate the monocyte to HDL ratio (MHR) as a predictor of 30-day mortality in patients with acute ischemic stroke (AIS).
Main Methods:
- Retrospective analysis of 466 AIS patients diagnosed between January 2008 and June 2016.
- Comparison of monocyte counts, HDL levels, and MHR values between AIS patients and 408 controls.
- Classification of AIS patients into survivors and non-survivors based on 30-day mortality.
Main Results:
- AIS patients exhibited higher MHR values compared to controls due to elevated monocyte counts and lower HDL levels.
- Non-surviving AIS patients had significantly higher monocyte counts and MHR values, and lower HDL levels (p<0.001).
- MHR was identified as a significant independent predictor of 30-day mortality in AIS patients, with an optimal cut-off of 17.52.
Conclusions:
- Elevated MHR is an independent predictor of 30-day mortality in patients diagnosed with acute ischemic stroke (AIS).
Related Concept Videos
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
01:26Coronary Artery Disease IV: Preventive Measures
01:26Atherosclerosis III: Management
01:17Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...