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Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
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Fast-TRKing Drug Development for Rare Molecular Targets.

Aparna R Parikh1, Ryan B Corcoran2

  • 1Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts.

Cancer Discovery
|September 3, 2017
PubMed
Summary

Developing drugs for rare cancer targets like TRK fusions is hard. A new TRK inhibitor, LOXO-195, shows promise in overcoming resistance mutations, offering new hope for patients.

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