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Updated: Feb 23, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Bipolar disorder and addictions: the elephant in the room
Paul R A Stokes1, Nicola J Kalk2, Allan H Young2
1Paul R. A. Stokes, PhD, Nicola J. Kalk, PhD, Allan H. Young, FRCPsych, Centre far Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK paul.r.stokes@kcl.ac.uk.
Abstract:
Addictions are highly prevalent in bipolar disorder and greatly affect clinical outcomes. In this editorial, we review the evidence that addictions are a key challenge in bipolar disorder, examine putative neurobiological mechanisms, and reflect on the limited clinical trial evidence base with suggestions for treatment strategies and further developments.
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