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Oxytocin and Aggression.

Trynke R de Jong1, Inga D Neumann2

  • 1Department of Behavioral and Molecular Neurobiology, University of Regensburg, 93053, Regensburg, Germany.

Current Topics in Behavioral Neurosciences
|September 3, 2017
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Summary
This summary is machine-generated.

Oxytocin (OT) is linked to social behavior, but a deficient OT system may cause aggression. While research supports this link, synthetic OT

Keywords:
AggressionCU traitsConduct disorderOxytocinResident-intruder test

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Behavioral Science

Background:

  • The neuropeptide oxytocin (OT) is widely recognized for its role in social behaviors like bonding, trust, and empathy.
  • A hypothesis suggests that impairments in the endogenous OT system could lead to antisocial behaviors, including social withdrawal and aggression.

Purpose of the Study:

  • To review evidence linking a hypo-oxytocinergic state to aggressive and antisocial behavior in animal and human studies.
  • To examine the effects of synthetic OT administration on aggression in various species.

Main Methods:

  • Literature review of animal and human studies investigating the oxytocin system and aggression.
  • Analysis of research on the impact of exogenous oxytocin administration on aggressive behaviors.

Main Results:

  • Evidence generally supports a correlation between down-regulated or impaired oxytocin system activity and increased aggression.
  • The anti-aggressive effects of synthetic oxytocin are not consistently straightforward and warrant further investigation.
  • Findings contribute to an ongoing debate regarding the unidirectional pro-social role of oxytocin and the efficacy of intranasal OT administration.

Conclusions:

  • While a hypo-oxytocinergic state is linked to aggression, the therapeutic potential of synthetic oxytocin requires more research.
  • The complex relationship between oxytocin and aggression challenges simplistic views of its pro-social functions.
  • Further studies are needed to clarify the precise mechanisms and effectiveness of oxytocin in modulating aggressive behaviors.