Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diels–Alder Reaction: Characteristics of Dienes01:29

Diels–Alder Reaction: Characteristics of Dienes

5.6K
The Diels–Alder reaction brings together a diene and a dienophile to form a six-membered ring. Both components have unique characteristics that influence the rate of the reaction.
Characteristics of the diene
Conformation
The simplest example of a diene is 1,3-butadiene, an acyclic conjugated π system. At room temperature, the molecule exists as a mixture of s-cis and s-trans conformers by virtue of rotation around the carbon–carbon single bond. Although the s-trans isomer is more stable,...
5.6K
Structure of Conjugated Dienes01:16

Structure of Conjugated Dienes

7.7K
Introduction
Conjugated dienes are compounds characterized by the presence of alternating double and single bonds. In a conjugated system like 1,3-butadiene, the unhybridized 2p orbital on each carbon overlaps continuously, allowing the π electrons to be delocalized across the entire molecule. In contrast, this type of overlap does not occur in cumulated and isolated dienes, such as 2,3-pentadiene and 1,4-pentadiene, respectively. Instead, the π electrons remain localized between the double...
7.7K
Diencephalon: Anatomical Regions01:30

Diencephalon: Anatomical Regions

5.8K
The diencephalon, etymologically translated as 'through brain,' plays an integral role as the conduit between the cerebrum and the vast extent of the nervous system. However, the olfactory system is an exception, as it interfaces directly with the cerebrum. The diencephalon, deeply ensconced beneath the cerebrum, primarily consists of three paired structures — the thalamus, hypothalamus, and epithelamus. It also includes accessory structures such as the subthalamus, which houses the...
5.8K
The Blood-brain Barrier00:49

The Blood-brain Barrier

53.9K
Overview
53.9K
Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry01:29

Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry

6.1K
Diels–Alder reactions between cyclic dienes locked in an s-cis configuration and dienophiles yield bridged bicyclic products.
6.1K
Stability of Conjugated Dienes01:28

Stability of Conjugated Dienes

4.5K
Introduction
A comparison of the enthalpies of hydrogenation of dienes reveals that conjugated dienes release less heat on hydrogenation, rendering them more stable than their nonconjugated analogs.
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Closed, pumpless microphysiological system with unidirectional flow for co-culture and focal irradiation.

RSC advances·2026
Same author

Drebrin is a novel biomarker of cognitive deterioration in Alzheimer's disease.

Journal of Alzheimer's disease : JAD·2026
Same author

Addiction-related problems in Japan: A regional perspective.

Addiction (Abingdon, England)·2025
Same author

Nilotinib impairs relaxation and temporal electro-mechanical integrity in human iPS-derived cardiomyocyte sheets.

Toxicology and applied pharmacology·2025
Same author

Human-Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Showed Neuronal Differentiation, Neurite Extension, and Formation of Synaptic Structures in Rodent Ischemic Stroke Brains.

Cells·2024
Same author

Secondary Publication: Proposal for Points of Consideration for Pluripotent Stem Cell Culture.

In vitro cellular & developmental biology. Animal·2024

Related Experiment Video

Updated: Feb 23, 2026

Easy and Reproducible Low-Density Primary Culture using Frozen Stock of Embryonic Hippocampal Neurons
04:26

Easy and Reproducible Low-Density Primary Culture using Frozen Stock of Embryonic Hippocampal Neurons

Published on: January 27, 2023

2.9K

General Introduction to Drebrin.

Tomoaki Shirao1, Yuko Sekino2

  • 1Department of Neurobiology and Behavior, Gunma University Graduate School of Medicine, Maebashi, Gunma, 371-8511, Japan. tshirao@gunma-u.ac.jp.

Advances in Experimental Medicine and Biology
|September 3, 2017
PubMed
Summary
This summary is machine-generated.

Drebrin is an actin-binding protein crucial for cell communication and neuronal function. Its isoforms, drebrin A and E, play distinct roles in synaptogenesis, synaptic plasticity, and cellular processes, with deficiencies linked to neurological disorders and cancer metastasis.

Keywords:
Alternative splicingCancerCell migrationIntercellular communicationPhysical property of actin filamentSynaptic plasticitySynaptogenesis

More Related Videos

Focused Ultrasound Induced Blood-Brain Barrier Opening for Targeting Brain Structures and Evaluating Chemogenetic Neuromodulation
08:37

Focused Ultrasound Induced Blood-Brain Barrier Opening for Targeting Brain Structures and Evaluating Chemogenetic Neuromodulation

Published on: December 22, 2020

4.4K
Non-invasive Strategies for Chronic Manipulation of DREADD-controlled Neuronal Activity
08:28

Non-invasive Strategies for Chronic Manipulation of DREADD-controlled Neuronal Activity

Published on: August 25, 2019

14.6K

Related Experiment Videos

Last Updated: Feb 23, 2026

Easy and Reproducible Low-Density Primary Culture using Frozen Stock of Embryonic Hippocampal Neurons
04:26

Easy and Reproducible Low-Density Primary Culture using Frozen Stock of Embryonic Hippocampal Neurons

Published on: January 27, 2023

2.9K
Focused Ultrasound Induced Blood-Brain Barrier Opening for Targeting Brain Structures and Evaluating Chemogenetic Neuromodulation
08:37

Focused Ultrasound Induced Blood-Brain Barrier Opening for Targeting Brain Structures and Evaluating Chemogenetic Neuromodulation

Published on: December 22, 2020

4.4K
Non-invasive Strategies for Chronic Manipulation of DREADD-controlled Neuronal Activity
08:28

Non-invasive Strategies for Chronic Manipulation of DREADD-controlled Neuronal Activity

Published on: August 25, 2019

14.6K

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Neuroscience

Background:

  • Drebrin, a developmentally regulated brain protein, is an actin-binding protein encoded by the DBN1 gene.
  • Two major isoforms, drebrin A (neuron-specific) and drebrin E, arise from alternative splicing.
  • Drebrin A is concentrated in dendritic spines and its levels are modulated by synaptic activity.

Purpose of the Study:

  • To elucidate the distinct roles and functions of drebrin isoforms in cellular processes.
  • To investigate the involvement of drebrin in cell-cell communication and its implications in disease.

Main Methods:

  • Alternative splicing analysis of the DBN1 gene.
  • Immunohistochemistry to determine drebrin localization.
  • Cellular assays to assess drebrin's role in migration and cell process formation.

Main Results:

  • Drebrin A, with its neuron-specific Ins2 sequence, is vital for synaptic function.
  • Drebrin E is expressed in various cell types and involved in diverse cellular mechanisms.
  • Lack of drebrin disrupts cell-cell communication, leading to aberrant cell migration, synaptic dysfunction, and endothelial integrity issues.

Conclusions:

  • Drebrin isoforms are critical regulators of cell-cell communication and cytoskeletal organization.
  • Dysfunctional drebrin is implicated in neurological diseases like dementia and cancer metastasis.
  • Drebrin's unique F-actin binding may facilitate molecular assembly platforms essential for intercellular signaling.