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Updated: Feb 23, 2026

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients
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A Longitudinal Study of PROMIS Pediatric Symptom Clusters in Children Undergoing Chemotherapy

Jichuan Wang1, Shana Jacobs1, Darren A Dewalt2

  • 1Children's National Health System, The George Washington University, Washington, DC, USA.

Journal of Pain and Symptom Management
|September 4, 2017
PubMed

Insights

Pediatric cancer patients show distinct symptom profiles during chemotherapy. A single fatigue question at the start can predict these profiles and their changes over time, aiding care.

Area of Science:

  • Pediatric Oncology
  • Symptom Management
  • Health Outcomes Research

Background:

  • Children undergoing cancer treatment often experience multiple, interconnected symptoms.
  • Understanding symptom patterns and their evolution is crucial for developing effective patient care strategies.

Purpose of the Study:

  • To identify distinct symptom profiles in pediatric cancer patients using Patient-Reported Outcomes Measurement Information System (PROMIS) measures.
  • To examine how these symptom profiles change during a chemotherapy cycle.
  • To determine if baseline fatigue predicts symptom profile status and its changes.

Main Methods:

  • Longitudinal study with three data points (T1, T2, T3) involving 96 children (8-18 years).
  • Utilized PROMIS Pediatric short form measures for fatigue, depression, anxiety, and pain.
  • Employed latent profile analysis and latent transition analysis.

Main Results:

  • Two latent symptom profiles were identified: 'less severe symptoms' and 'severe symptoms'.
  • The 'severe symptoms' profile prevalence decreased significantly by T3 (end of cycle).
  • Baseline fatigue scores accurately predicted profile membership and subsequent changes.

Conclusions:

  • Pediatric cancer patients exhibit heterogeneous symptom experiences during chemotherapy.
  • Two distinct, previously unknown symptom profiles emerged.
  • Early fatigue assessment is a valuable predictor of symptom trajectory and can inform clinical management.
Abstract

Keywords:
Pediatric oncologydepressionfatiguelatent group analysispainsymptom cluster

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