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Updated: Feb 23, 2026
Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
Published on: July 27, 2022
A graded graphene oxide-hydroxyapatite/silk fibroin biomimetic scaffold for bone tissue engineering
Qian Wang1, Yanyan Chu1, Jianxin He1
1Henan Provincial Key Laboratory of Functional Textile Materials, Zhongyuan University of Technology, Zhengzhou 450007, China; Collaborative Innovation Center of Textile and Garment Industry, Henan Province, Zhengzhou 450007, China.
Abstract:
To better mimic natural bone, a graphene oxide-hydroxyapatite/silk fibroin (cGO-HA/SF) scaffold was fabricated by biomineralizing carboxylated GO sheets, blending with SF, and freeze-drying. The material has increasing porosity and decreasing density from outside to inside. Analysis of GO mineralization in simulated body fluid indicated that carboxylation and Chitosan may synergistically regulate HA growth along the c-axis of weakly crystalline, rod-like GO-HA particles. Compared with HA/SF gradient composites, a cGO-HA gradient scaffold with cGO:HA mass ratio 1:4 has 5-fold and 2.5-fold higher compressive strength and compressive modulus, respectively. Additionally, the cGO-HA/SF composite stimulated mouse mesenchymal stem cell adhesion and proliferation, alkaline phosphatase secretion, and mineral deposition more strongly than HA/SF and pure HA scaffolds. Hence, the material may prove to be an excellent and versatile scaffold for bone tissue engineering.
