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Development of polyurethanes for bone repair.

M Marzec1, J Kucińska-Lipka1, I Kalaszczyńska2

  • 1Department of Polymer Technology, Faculty of Chemistry, Gdansk University of Technology, Narutowicza 11/12, 80-233 Gdansk, Poland.

Materials Science & Engineering. C, Materials for Biological Applications
|September 4, 2017
PubMed
Summary

This review covers recent advances in polyurethanes for bone tissue engineering, focusing on their design, synthesis, and biological properties for bone regeneration applications.

Keywords:
BiocompatibilityBone tissue engineeringCalcificationCellsPolyurethane

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Polymer Chemistry

Background:

  • Polyurethanes are versatile polymers with tunable properties.
  • Their application in bone tissue engineering requires understanding their biological interactions.

Purpose of the Study:

  • To review recent developments in polyurethanes for bone tissue engineering.
  • To discuss their design, synthesis, modifications, and biological properties.

Main Methods:

  • Literature review of polyurethanes in bone tissue engineering.
  • Analysis of structure-property relationships (e.g., hard/soft segment ratio, stiffness).
  • Evaluation of biodegradation, biocompatibility, and bioactivity.

Main Results:

  • Polyurethanes exhibit tunable biodegradation, biocompatibility, and bioactivity.
  • Strategies like incorporating biomolecules, surface modifications, and creating composites enhance performance.
  • Specific applications include bone void fillers, shape memory scaffolds, and drug carriers.

Conclusions:

  • Polyurethanes show significant promise for bone regeneration.
  • Further research into enhancing their bioactivity and integration is crucial for clinical translation.