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Circulating interleukin-6 levels and cardiovascular and all-cause mortality in the elderly population: A
Honghong Li1, Wenjuan Liu2, Jiemei Xie3
1Department of Public Health, Shandong Province Yantai City Yuhuangding Hospital, Yantai 264000, China.
Objective:
Inflammatory markers may be associated with mortality in the elderly population. We conducted this meta-analysis to evaluate the association of elevated circulating interleukin-6 levels with cardiovascular or all-cause mortality in the general elderly population.
Methods:
A comprehensive literature search was conducted through the Pubmed and Embase databases until April 2016. Prospective observational studies that investigated the association of circulating interleukin-6 levels with cardiovascular or all-cause mortality in the elderly general population (aged 60 years or more) were included. Pooled risk ratio (RR) and 95% confidence intervals (CI) were calculated by the highest vs. the lowest interleukin-6 levels.
Results:
Nine prospective studies involving 9087 participants were identified. When comparing the highest with the lowest interleukin-6 levels, the pooled RR of all-cause mortality and cardiovascular mortality were 1.49 (95% CI 1.33-1.67) and 1.69 (95% CI 1.27-2.25), respectively. Subgroup analysis indicated the effects of interleukin-6 on all-cause mortality were consistently observed in sample sizes, region, durations of follow-up, interleukin-6 cutoff value and number of adjusted for covariates subgroups.
Conclusions:
This meta-analysis indicates that elevated circulating interleukin-6 levels are independently associated with greater risk of cardiovascular and all-cause mortality in the general elderly population.
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