Noradrenaline-sensitive cyclic AMP-generating system of rat cerebral cortex with iron-induced epileptiform activity

Noradrenaline-elicited accumulation of cyclic AMP and effects of an alpha-, beta-adrenoceptor, or adenosine receptor antagonist on the accumulation were examined in slices of different areas of rat cerebral cortex in which ferrous chloride solution was injected unilaterally into the sensorimotor cortex to induce epileptiform activity. The cyclic AMP accumulation was altered regionally in relation to both lateral dominance of electrographic isolated spike activity and variance of the epileptic process. Involvement of a beta-adrenergic, and possibly alpha-adrenergic, mechanism in the alterations in the cyclic AMP accumulation was indicated.