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Updated: Aug 16, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
[Long term outcome of perinatal stroke]
C Vuillerot1, S Marret2, M Dinomais3
1L'Escale médecine physique et réadaptation, hôpital Femme-Mère-Enfant, CHU de Lyon, 59, boulevard Pinel, Bron, F-69677 France; CNRS UMR 5558, laboratoire de biométrie et biologie évolutive, équipe Biostatistiques Santé, Pierre-Bénite, 69310 France; université de Lyon, Lyon, 69000 France.
Insights
Neonatal arterial ischemic stroke (NAIS) can lead to long-term motor and cognitive deficits in newborns. Early, multidisciplinary monitoring is crucial for managing these impairments and improving outcomes for affected children.
Area of Science:
- Neurology
- Pediatrics
- Developmental Psychology
Background:
- Neonatal Arterial Ischemic Stroke (NAIS) impacts 6-17 per 100,000 term neonates.
- Most affected children experience lasting motor and cognitive impairments.
Purpose of the Study:
- To describe motor and cognitive outcomes following NAIS.
- To propose a standardized monitoring approach for improved management of affected children.
Main Methods:
- Literature review on NAIS outcomes.
- Analysis of existing data on child development post-NAIS.
Main Results:
- Approximately 30% develop unilateral cerebral palsy, necessitating specialized rehabilitation.
- 50-90% experience speech and language disorders, unlike adult aphasia.
- Global intellectual function is typically preserved unless lesions are extensive or epilepsy is severe.
- Visuospatial functions may be particularly vulnerable.
Conclusions:
- Systematic, early, and annual evaluations using validated tools are essential until puberty.
- A multidisciplinary team approach with longitudinal follow-up across all developmental domains is recommended.
- Evaluating family functioning is vital for supporting coping mechanisms.
Abstract:
Neonatal Arterial Ischemic Stroke (NAIS) affects 6-17 newborns on 100 000-birth term neonates, most of these children keeping long-term motor and cognitive impairments. Based on a literature review, the objectives of this paper are to describe motor and cognitive outcomes after a NAIS and to propose a consensual monitoring of these children to improve their management. About 30 % of children after a NAIS will develop a unilateral cerebral palsy requiring a management by a team with expertise in physical medicine and rehabilitation. Unlike adults, especially after a left NAIS, children will not present aphasia but between 50 and 90 % will present disorders of speech and language in expression and/or reception. After NAIS, the global intellectual efficiency is usually preserved except when the size of the lesion is very important or when severe epilepsy occurs. Several studies are also in favor of vulnerability in visuospatial functions. To quantify impairments, activity limitations and participation restrictions resulting from this NAIS, early and at least yearly evaluations with reliable tools must be carried out systematically until puberty. A multidisciplinary team with a longitudinal follow-up, in all the different developmental dimensions, must conduct these evaluations in term of motor skills, cognitive impairment, behavior, autonomy, quality of life, and participation. Consequences on family functioning need to be evaluate in order to help children and family coping with this event.
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