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Collective Growth in a Small Cell Network.

Jasmin Imran Alsous1, Paul Villoutreix2, Alexander M Berezhkovskii3

  • 1Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA; The Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.

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|September 5, 2017
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Summary
This summary is machine-generated.

Cell size in Drosophila melanogaster germline cysts is determined by proximity to the oocyte, influencing collective cell growth. A mathematical model explains this emergent pattern and reveals allometric growth.

Keywords:
Drosophilacollective growthemergent behaviornetworksoogenesis

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Area of Science:

  • Developmental Biology
  • Systems Biology
  • Cell Biology

Background:

  • Emergent properties in multicellular systems can arise in small networks.
  • Experimental models for studying collective dynamics in defined cell networks are limited.
  • The Drosophila melanogaster female germline cyst is a 16-cell network with significant growth and unequal cell volume distribution.

Purpose of the Study:

  • To investigate collective cell behavior and growth patterns in the Drosophila melanogaster female germline cyst.
  • To identify factors determining cell size and growth within this multicellular network.
  • To develop a mathematical model explaining emergent cell size patterns.

Main Methods:

  • Quantification of multicellular growth at single-cell resolution.
  • Analysis of cell size based on network proximity to the oocyte.
  • Development of a mathematical model incorporating intercellular transport on a cell lineage tree.

Main Results:

  • Cell size is primarily determined by proximity to the oocyte within the network.
  • Cells exhibit group growth patterns influenced by their position.
  • The proposed mathematical model accurately predicts the divergent cell size pattern.
  • Allometric growth of cells within the network was identified as an emergent property.

Conclusions:

  • Oocyte proximity is the key factor driving cell size determination and collective growth in the germline cyst.
  • Intercellular transport on the cell lineage tree is crucial for understanding emergent growth patterns.
  • The study provides insights into differential growth mechanisms relevant to organismal development.