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Riluzole-induced recurrent pancreatitis.
Catarina Falcão de Campos1, Mamede de Carvalho2
1Department of Neurology, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Portugal.
Summary
Riluzole, the sole drug for Amyotrophic Lateral Sclerosis (ALS), may rarely cause severe acute pancreatitis (AP). Discontinuing riluzole might prevent recurrent AP in ALS patients.
Area of Science:
- Neurology
- Gastroenterology
- Pharmacology
Background:
- Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease.
- Riluzole is the only FDA-approved medication for ALS treatment.
- Riluzole is generally well-tolerated, with common side effects including asthenia, nausea, and elevated liver enzymes.
Observation:
- Two patients with sporadic limb-onset ALS developed recurrent acute pancreatitis (AP).
- Portal vein thrombosis was observed as a complication in one patient.
- Both patients were undergoing treatment with riluzole.
Findings:
- Acute pancreatitis (AP) is identified as a potential rare and severe adverse effect of riluzole.
- The occurrence of AP in ALS patients treated with riluzole is reported for the first time.
- Recurrent AP was observed in patients during riluzole therapy.
Implications:
- Clinicians should consider AP as a possible side effect in ALS patients treated with riluzole.
- Withdrawing riluzole may be a strategy to prevent recurrent AP.
- Further investigation into the link between riluzole and AP is warranted.
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