Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to Lymphatic and Immune System01:23

Introduction to Lymphatic and Immune System

18.3K
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...
18.3K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

9.4K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
9.4K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

9.8K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
9.8K
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

3.5K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
3.5K
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

7.3K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
7.3K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

84.7K
Overview
84.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same author

Interleukin-12 induces rapid STAT4/DDX5-dependent remodeling of RNA polymerase II occupancy in NK cells.

The Journal of experimental medicine·2026
Same author

Molecular determinants of NK cell memory.

Trends in immunology·2026
Same author

TOX drives CD4<sup>+</sup> T<sub>H</sub>1 effector function, antitumor immunity and autoimmune pathology.

Nature immunology·2026
Same author

Stem-like memory-T maintenance and differentiation into tissue-resident T cells sustain chronic graft-versus-host disease in mice.

Nature communications·2026
Same author

The transcriptional repressor Fli1 inhibits proteostasis during nutrient stress to limit NK cell persistence in solid tumors.

Immunity·2026
Same journal

BindRNAgen: Protein-binding RNA sequence generation using latent diffusion models.

Journal of molecular biology·2026
Same journal

Structural basis of HSP90C, a highly active chloroplastic HSP90 chaperone from Arabidopsis thaliana.

Journal of molecular biology·2026
Same journal

Clinical inflammasome biomarkers: Progress and prospects.

Journal of molecular biology·2026
Same journal

Biologically Relevant, Cationic Residues in Human Rhinovirus Stabilize Capsid-Bound RNA Duplexes, and Restrict Capsid Flexibility.

Journal of molecular biology·2026
Same journal

Cryo-EM structures of phage T4 infection intermediate.

Journal of molecular biology·2026
Same journal

A classic fold with a twist: Structural architecture of Dhillonvirus phage Bas18.

Journal of molecular biology·2026
See all related articles

Related Experiment Video

Updated: Feb 23, 2026

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
11:12

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Published on: September 13, 2024

979

Innate Lymphoid Cell Immunometabolism.

Timothy E O'Sullivan1, Joseph C Sun2

  • 1Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, United States.

Journal of Molecular Biology
|September 5, 2017
PubMed
Summary
This summary is machine-generated.

Innate lymphoid cells (ILCs) are crucial immune cells impacting metabolism. This review explores how ILCs influence host metabolism and how metabolic changes regulate ILC biology, highlighting the field of immunometabolism.

Keywords:
innate lymphoid cellsmetabolism

More Related Videos

Measuring Mitochondrial Function of Na&#239;ve and Effector CD8 T Cells
06:07

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

1.2K
Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes
06:26

Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes

Published on: March 28, 2025

1.0K

Related Experiment Videos

Last Updated: Feb 23, 2026

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
11:12

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Published on: September 13, 2024

979
Measuring Mitochondrial Function of Na&#239;ve and Effector CD8 T Cells
06:07

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

1.2K
Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes
06:26

Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes

Published on: March 28, 2025

1.0K

Area of Science:

  • Immunology
  • Metabolism
  • Cell Biology

Background:

  • Innate lymphoid cells (ILCs) are key immune cells protecting epithelial barriers.
  • Dysregulated ILCs can contribute to disease pathology.
  • The interplay between ILCs and their environment significantly affects host metabolism.

Purpose of the Study:

  • To review the bidirectional relationship between ILCs and host metabolism.
  • To highlight the influence of ILCs on tissue and systemic metabolism.
  • To discuss how metabolic changes impact ILC biology and function.

Main Methods:

  • Literature review of recent studies on ILCs and immunometabolism.
  • Analysis of research on ILC-environment metabolic crosstalk.
  • Examination of studies on ILC-intrinsic metabolic regulation.

Main Results:

  • ILCs significantly influence tissue and systemic metabolism.
  • Environmental metabolic changes modulate ILC biology, activation, and homeostasis.
  • ILC-intrinsic metabolism is critical for their function and survival.

Conclusions:

  • The field of immunometabolism is rapidly expanding.
  • Understanding ILC-metabolism interactions is crucial for health and disease.
  • Further research is needed to address challenges and open questions in ILC immunometabolism.