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Updated: Feb 23, 2026

Investigating Single Molecule Adhesion by Atomic Force Spectroscopy
Published on: February 27, 2015
Relationship between Hydrogen-bond Conditions of Surface Adsorbed Water and Interparticle Binding Force on
Taketoshi Ito1,2, Hidehiro Kamiya1
1Graduate School of Bio-Applications and System Engineering, Tokyo University of Agriculture and Technology.
Abstract:
Influence of water contents to the pharmaceutical tablet strength is known empirically, and participation of hydrogen bonding force among adsorbed water molecules has been presumed. However, the detailed mechanisms of hydrogen bonding phenomena have not been reported. In this study, the hydrogen bonds states of the surface adsorbed waters on the excipient particles of the tablets were focused upon, and the relationship to the interparticle binding force determined by the Rumpf equation was discussed using a near-infrared spectroscopy (NIR). As for the results, NIR peaks of OH groups of surface water were shifted by a humidity change, and the degrees of the peak shifts correlated to interparticle binding force.
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