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Multiple Pigmented Conjunctival Lesions following Intravitreal Injections in a Patient with Uveal Melanoma
Niels J Brouwer1, Gregorius P M Luyten1, Sjoerd G van Duinen2
1Department of Ophthalmology, Leiden University Medical Centre, Leiden, The Netherlands.
Purpose:
This paper reports a case of pigmented conjunctival lesions after intravitreal injections in a patient who received brachytherapy for uveal melanoma.
Methods:
Clinical and histopathological examination of the pigmented conjunctival lesions was performed.
Results:
A 57-year-old male who was treated with brachytherapy for uveal melanoma developed radiation retinopathy. Following intravitreal anti-vascular endothelial growth factor (VEGF) injections, 2 pigmented conjunctival spots appeared at the injection sites. After excision of the lesions, histopathology showed pigment-loaded macrophages, with no signs of active tumour cells.
Conclusion:
Two conjunctival lesions that appeared following uveal melanoma brachytherapy and anti-VEGF injections were excised under suspicion of tumour seeding. Histopathology, however, showed aggregates of pigment-loaded macrophages.
