Related Experiment Video
Updated: Feb 23, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Pathophysiological Mechanisms in Sclerosing Skin Diseases
Beate Eckes1, Fang Wang1, Pia Moinzadeh1
1Department of Dermatology, University of Cologne, Cologne, Germany.
Abstract:
Sclerosing skin diseases represent a large number of distinct disease entities, which include systemic sclerosis, localized scleroderma, and scleredema adultorum. These pathologies have a common clinical appearance and share histological features. However, the specific interplay between cytokines and growth factors, which activate different mesenchymal cell populations and production of different extracellular matrix components, determines the biomechanical properties of the skin and the clinical features of each disease. A better understanding of the mechanisms underlying these events is prerequisite for developing novel targeted therapeutic approaches.
Related Concept Videos
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Atherosclerosis I: Introduction
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Desmosomes
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
Coronary Artery Disease II: Pathophysiology

