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Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
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Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes

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Maternal vitamin D and offspring trabecular bone score.

N K Hyde1, S L Brennan-Olsen2,3,4, J D Wark5

  • 1Epi-Centre for Healthy Ageing, IMPACT SRC, School of Medicine, Deakin University (Barwon Health), PO Box 281, Geelong, VIC, 3220, Australia. nhyde@barwonhealth.org.au.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
|September 5, 2017
PubMed
Summary

Maternal vitamin D levels in early pregnancy are linked to offspring bone health in boys. This study suggests a connection between maternal 25-hydroxyvitamin D and trabecular bone score in male children.

Keywords:
MaternalOffspringPregnancyTrabecular bone scoreVitamin D

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Area of Science:

  • Bone microarchitecture research
  • Maternal-fetal health studies
  • Vitamin D metabolism and skeletal development

Background:

  • Trabecular bone score (TBS) assesses vertebral microarchitecture using DXA, predicting fractures independently of bone mineral density.
  • Previous research linked maternal vitamin D to offspring bone mineral content at age 11.
  • The association between maternal vitamin D and offspring TBS has not been previously investigated.

Purpose of the Study:

  • To determine the association between maternal serum 25-hydroxyvitamin D (25(OH)D) levels during pregnancy and offspring trabecular bone score (TBS) at age 11.
  • To explore potential sex-specific differences in this association.

Main Methods:

  • Data from the Vitamin D in Pregnancy (VIP) study were analyzed.
  • Maternal 25(OH)D was measured via radioimmunoassay in early and late pregnancy.
  • Offspring underwent spine DXA at age 11, with TBS calculated using specialized software.

Main Results:

  • Higher maternal 25(OH)D levels (≥50 nmol/L) at recruitment were associated with higher offspring TBS (p=0.04).
  • A 10 nmol/L increase in maternal 25(OH)D was linked to a 0.005 increase in offspring TBS (p=0.04), particularly in boys.
  • No significant association was found between maternal 25(OH)D in late pregnancy and offspring TBS.

Conclusions:

  • Maternal 25(OH)D in early pregnancy may be associated with offspring TBS at age 11, specifically in boys.
  • These findings are hypothesis-generating and require confirmation in larger studies.
  • Further research should focus on interventional and long-term follow-up studies to validate these results.