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Successful Use of Enzyme Replacement Therapy in Infantile Hypophosphatasia

Peter J Simm1,2,3, Ravi Savarirayan2,3,4

  • 1Department of Endocrinology and Diabetes, Royal Children's Hospital, Melbourne, Victoria, Australia.

Journal of Paediatrics and Child Health
|September 5, 2017
PubMed
Abstract

No abstract available in PubMed .

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In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
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