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[One year persistence of free and fixed dose combinations of perindopril/amlodipine]

Gábor Simonyi1, Tamás Ferenci2, Mihály Medvegy3

  • 1Anyagcsere Központ, Szent Imre Egyetemi Oktatókórház Budapest, Tétényi út 12-16., 1115.

Orvosi Hetilap
|September 5, 2017
PubMed

Insights

Fixed-dose combination perindopril/amlodipine significantly improved medication adherence in hypertension patients compared to free combinations. This suggests fixed-dose combinations are more effective for long-term hypertension management and cardiovascular risk reduction.

Area of Science:

  • Cardiology
  • Pharmacology
  • Public Health

Background:

  • Patient adherence is crucial for effective hypertension management and cardiovascular risk reduction.
  • Prolonged and effective pharmacotherapy is essential for controlling hypertension.

Purpose of the Study:

  • To compare the one-year treatment persistence of free and fixed-dose combinations of perindopril/amlodipine in hypertension patients.
  • To evaluate the impact of combination formulation on adherence to antihypertensive therapy.

Main Methods:

  • Analysis of Hungarian National Health Insurance prescription data (Oct 2012 - Sep 2013).
  • Inclusion of newly diagnosed hypertension patients initiating perindopril/amlodipine therapy.
  • Application of discrete time survival analysis to determine medication discontinuation times.

Main Results:

  • A total of 109,248 patients were analyzed.
  • One-year persistence rates were 27.15% for free combinations and 46.89% for fixed-dose combinations.
  • The fixed-dose combination showed a significantly lower discontinuation rate (HR=1.94) and longer persistence (245.7 days vs. 177.6 days).

Conclusions:

  • Fixed-dose combination perindopril/amlodipine demonstrates superior one-year treatment persistence compared to free combinations in hypertension management.
  • Improved adherence with fixed-dose combinations can lead to more effective and sustained pharmacotherapy for cardiovascular risk reduction.
Abstract

Keywords:
adherenceadherenciaantihipertenzív terápiaantihypertensive therapyperindopril/amlodipin kombinációkperindopril/amlodipine combinationspersistenceperzisztencia

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