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Surgical Model for Single-Staged Tissue-Engineered Urothelial Tubes in Minipigs
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Tissue - engineering as an adjunct to pelvic reconstructive surgery.

Hanna Jangö1

  • 1hanna@jango.se.

Danish Medical Journal
|September 5, 2017
PubMed
Summary

Tissue engineering using muscle fiber fragments (MFFs) on a methoxypolyethyleneglycol-poly(lacticco-glycolic acid) scaffold aids pelvic reconstructive surgery. Polycaprolactone scaffolds provide reinforcement but do not support MFFs due to inflammation.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Obstetrics and Gynecology

Background:

  • Pelvic organ prolapse (POP) repair strategies require improvement due to poor outcomes with native tissue repair and adverse effects from permanent meshes.
  • Tissue engineering offers a regenerative approach using stem cells, scaffolds, and trophic factors for functional tissue creation.

Purpose of the Study:

  • To investigate the adjunctive use of tissue engineering in pelvic reconstructive surgery.
  • To evaluate synthetic biodegradable materials, methoxypolyethyleneglycol-poly(lacticco-glycolic acid) (MPEG-PLGA) and electrospun polycaprolactone (PCL), with or without autologous muscle fiber fragments (MFFs).

Main Methods:

  • Utilized animal models (rats and rabbits) to simulate POP repair scenarios.
  • Assessed MPEG-PLGA scaffolds with MFFs in rat abdominal wall defect models.

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  • Evaluated PCL scaffolds with and without MFFs in rat abdominal wall models and developed a rabbit vaginal model.

    • Main Results:

    • MPEG-PLGA scaffolds degraded within eight weeks, supporting MFF survival and regeneration of striated muscle fibers, leading to biomechanical improvements.
    • PCL scaffolds induced a significant foreign-body response, forming a strong neotissue construct but failing to support MFF survival.
    • A transabdominal rabbit vaginal model proved feasible for evaluating mesh implantation without erosion.

    Conclusions:

    • MFFs on MPEG-PLGA scaffolds show potential for tissue regeneration in pelvic reconstructive surgery.
    • PCL scaffolds offer biomechanical reinforcement but are unsuitable for cell delivery due to inflammatory responses.
    • The developed rabbit vaginal model is advantageous for evaluating meshes in pelvic reconstructive surgery.