Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hepatic Drug Clearance: Role of Transporters01:14

Hepatic Drug Clearance: Role of Transporters

337
In the liver and bile canaliculi, influx and efflux transporters modification can influence intrinsic clearance. Transporters play a significant role in moving drugs within liver cells. Elaborate models, such as the Biopharmaceutical Classification System (BCS), are essential to relate transporters to drug disposition. This system categorizes drugs into four classes based on solubility and permeability, providing insights into elimination routes and the effects of transporters following oral...
337
Drug Absorption Mechanism: Passive Membrane Transport01:23

Drug Absorption Mechanism: Passive Membrane Transport

7.3K
Passive transport is a method of drug absorption where small, lipid-soluble drugs can move across the cell membrane. This movement happens along the concentration gradient, which is a natural flow from higher to lower concentration areas. The speed at which the drug moves is directly related to its lipid–water partition coefficient. This means that the more a drug dissolves in lipids, the faster it diffuses or spreads throughout the body. It is important to note that most drugs are either...
7.3K
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

1.8K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.8K
Factors Affecting Renal Clearance: Drug's Physicochemical Properties and Plasma Levels01:31

Factors Affecting Renal Clearance: Drug's Physicochemical Properties and Plasma Levels

645
Renal clearance of a drug is influenced by various factors, including its physicochemical properties and plasma levels. These factors play a significant role in determining how efficiently the kidneys eliminate a drug.
One important factor is the drug's molecular size. The kidneys readily excrete smaller molecules below 300 Daltons (Da). On the other hand, molecules weighing between 300 and 500 Da are excreted through both urine and bile. Larger molecules above 500 Da tend to be excreted...
645
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

612
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
612
Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH01:21

Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH

3.5K
Drug absorption within the gastrointestinal (GI) tract is a complex process influenced by several critical factors, including the site pH, the drug's dissociation constant (pKa), and the drug's lipophilicity. The GI tract exhibits a pH gradient, with an acidic environment in the stomach and a more alkaline environment in the small intestine. This pH variation directly affects the ionization state of drugs.
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Additively Manufactured <i>in planta</i> Integrated Microneedle-Microfluidic Sensing: Nondestructive Electrochemical Tracking of Glucose and Water Stress in Agricultural Crop Plants.

ACS sensors·2026
Same author

Relative Susceptibility of Common Cotton Cultivars to <i>Meloidogyne enterolobii</i>, <i>M. floridensis</i>, and <i>M. incognita</i> Isolates from Georgia, U.S.A.

Phytopathology·2026
Same author

Mapping QTLs for <i>Pyricularia</i> leaf spot, nematode resistance, and yield related traits in pearl millet [<i>Cenchrus americanus</i> (L.) Morrone].

Frontiers in plant science·2025
Same author

Differential Response of <i>Meloidogyne enterolobii</i>, <i>M. floridensis</i>, <i>M. haplanaria</i>, and <i>M. incognita</i> to Sublethal Doses of Nonfumigant Nematicides.

Phytopathology·2025
Same author

Reproduction of <i>Meloidogyne enterolobii</i> on Onion and Potential Yield Suppression.

Journal of nematology·2025
Same author

Time-course RNA-seq analysis of upland cotton (Gossypium hirsutum L.) responses to Southern root-knot nematode (Meloidogyne incognita) during compatible and incompatible interactions.

BMC genomics·2025

Related Experiment Video

Updated: Feb 23, 2026

Combined Size and Density Fractionation of Soils for Investigations of Organo-Mineral Interactions
08:38

Combined Size and Density Fractionation of Soils for Investigations of Organo-Mineral Interactions

Published on: February 15, 2019

15.8K

Fluensulfone sorption and mobility as affected by soil type.

Kelly A Morris1, Xiao Li2, David B Langston3

  • 1ADAMA, Agricultural Solutions Ltd, Raleigh, NC, USA.

Pest Management Science
|September 5, 2017
PubMed
Summary

Fluensulfone, a nematicide, shows varied soil adsorption and mobility influenced by soil properties like organic matter and clay content. Its dissipation in soil columns indicates moderate persistence, with higher concentrations remaining in the top soil layers.

Keywords:
HPLCdissipationfluensulfonenematicidesoils

More Related Videos

A Whole Cell Bioreporter Approach to Assess Transport and Bioavailability of Organic Contaminants in Water Unsaturated Systems
13:16

A Whole Cell Bioreporter Approach to Assess Transport and Bioavailability of Organic Contaminants in Water Unsaturated Systems

Published on: December 24, 2014

10.9K
Integrated Field Lysimetry and Porewater Sampling for Evaluation of Chemical Mobility in Soils and Established Vegetation
10:05

Integrated Field Lysimetry and Porewater Sampling for Evaluation of Chemical Mobility in Soils and Established Vegetation

Published on: July 4, 2014

14.9K

Related Experiment Videos

Last Updated: Feb 23, 2026

Combined Size and Density Fractionation of Soils for Investigations of Organo-Mineral Interactions
08:38

Combined Size and Density Fractionation of Soils for Investigations of Organo-Mineral Interactions

Published on: February 15, 2019

15.8K
A Whole Cell Bioreporter Approach to Assess Transport and Bioavailability of Organic Contaminants in Water Unsaturated Systems
13:16

A Whole Cell Bioreporter Approach to Assess Transport and Bioavailability of Organic Contaminants in Water Unsaturated Systems

Published on: December 24, 2014

10.9K
Integrated Field Lysimetry and Porewater Sampling for Evaluation of Chemical Mobility in Soils and Established Vegetation
10:05

Integrated Field Lysimetry and Porewater Sampling for Evaluation of Chemical Mobility in Soils and Established Vegetation

Published on: July 4, 2014

14.9K

Area of Science:

  • Agricultural Chemistry
  • Soil Science
  • Environmental Chemistry

Background:

  • Fluensulfone is a fluoroalkenyl chemical effective against plant-parasitic nematodes.
  • Understanding its environmental fate, specifically soil interactions, is crucial for agricultural applications.

Purpose of the Study:

  • To evaluate the adsorption, desorption, and mobility of fluensulfone in various US soils.
  • To determine the influence of soil properties on fluensulfone's environmental behavior.

Main Methods:

  • Laboratory batch experiments for adsorption/desorption using the Freundlich equation.
  • Soil column studies to assess fluensulfone mobility and leaching patterns.
  • Analysis of fluensulfone concentration in soil leachate and column sections.

Main Results:

  • Fluensulfone adsorption correlated positively with organic matter and clay, and negatively with sand.
  • Desorption varied significantly, with lower rates in sandy soils and higher rates influenced by pH and CEC.
  • Leachate analysis showed peak fluensulfone concentration at 3 hours, becoming undetectable by 9 hours, with 45% recovery.
  • Column studies revealed fluensulfone predominantly remained in the top 10-cm soil layer, with recovery ranging from 13% to 41%.

Conclusions:

  • Soil organic matter and clay content are key factors influencing fluensulfone sorption, mobility, and dissipation.
  • Fluensulfone exhibits moderate mobility and persistence in soil, with a tendency to remain in upper soil layers.