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Updated: Feb 23, 2026

Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells
Published on: February 15, 2019
Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever
Chad E Mire1,2, Robert W Cross1,2, Joan B Geisbert1,2
1Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Abstract:
There are no approved treatments for Lassa fever, which is endemic to the same regions of West Africa that were recently devastated by Ebola. Here we show that a combination of human monoclonal antibodies that cross-react with the glycoproteins of all four clades of Lassa virus is able to rescue 100% of cynomolgus macaques when treatment is initiated at advanced stages of disease, including up to 8 d after challenge.
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