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Intravenous-only or Intravenous Transitioned to Oral Antimicrobials for Enterobacteriaceae-Associated Bacteremic
Krista L Rieger1,2, John A Bosso1,2,3, Shawn H MacVane1,2
1Department of Pharmacy Services, Medical University of South Carolina, Charleston, South Carolina.
Pharmacotherapy
|September 5, 2017
Summary
Transitioning from intravenous to oral antibiotics for bacteremic Enterobacteriaceae urinary tract infections significantly reduced hospital stays and antibiotic days without increasing treatment failure. This approach offers a viable alternative to intravenous-only therapy.
Area of Science:
- Infectious Diseases
- Pharmacology
- Urology
Background:
- Bacteremic Enterobacteriaceae urinary tract infections (UTIs) require effective antibiotic treatment.
- Optimizing antibiotic regimens can improve patient outcomes and resource utilization.
Purpose of the Study:
- To compare treatment failure rates between intravenous-only and intravenous-to-oral transitioned antibiotic regimens for bacteremic Enterobacteriaceae UTIs.
- To analyze the impact of these regimens on hospital length of stay and antibiotic duration.
Main Methods:
- Retrospective cohort study.
- Involved 241 adult patients with bacteremic Enterobacteriaceae UTIs at a tertiary care academic medical center.
- Compared outcomes for intravenous-only versus intravenous-to-oral antibiotic treatment groups.
Main Results:
- The intravenous-to-oral group had significantly shorter hospital stays (4.6 vs. 7.1 days) and fewer hospital days on antibiotics (5 vs. 6 days).
- No statistically significant difference in treatment failure was observed between the intravenous-only (3.8%) and intravenous-to-oral (8.2%) groups (p=0.19).
Conclusions:
- Transitioning from intravenous to oral antibiotics is a viable strategy for treating bacteremic Enterobacteriaceae UTIs.
- This approach is associated with reduced hospital length of stay and antibiotic exposure.
- Further consideration of intravenous-to-oral transition can optimize patient care and resource management.
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