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The biochemical effects of nano tamoxifen and some bioactive components in experimental breast cancer
Afaf Ezzat1, Abdou Osman Abdelhamid2, Mostafa K El Awady3
1Department of Nutrition and Food Science, National Research Centre, Dokki, Cairo 12622, Egypt.
Abstract:
The effect of nano tamoxifen and some bioactive components such as yeast, isoflavone, and silymarin on the level of resistance and prevention of breast cancer progression in experimental animals is the target of this study. Thirty female Sprague-Dawley rats received a single medication dosage of 7,12-dimethylbenz[a]anthracene (DMBA) intragastrically. After fourteen days of DMBA admission, the procedure protocol started out. Finally, all the experimental results evaluated, tabulated and statistically analyzed. The results demonstrated a highly significant elevation in the 8-OHdG level in group 1 (nano yeast) and 3 (nano silymarin) while the results demonstrated a highly significant reduction in group 2 (nano tamoxifen). The apoptosis results demonstrated a significant elevation in group 3 (nano silymarin) where appeared significant reduction in group 4 (nano isoflavone). ErbB-2 results demonstrated a significant elevation in group 2 (nano tamoxifen) and a significant reduction in each of group 3 (nano silymarin) and 4 (nano isoflavone). The lipid peroxide level demonstrated an extremely significant reduction in group 4 (nano isoflavone). And a significant reduction of total antioxidant was observed in group 3 (nano silymarin) in comparison to injected animals control. This may be considered a new vision and strategy to resist breast cancer disease or prevent progression.
Insights
Nano yeast and silymarin increased oxidative stress markers, while nano tamoxifen reduced them. Nano silymarin boosted apoptosis, and nano isoflavone reduced lipid peroxides, offering potential breast cancer resistance strategies.
Area of Science:
- Biomedical Science
- Cancer Research
- Pharmacology
Background:
- Breast cancer remains a significant global health challenge.
- Developing novel therapeutic strategies for cancer prevention and treatment is crucial.
- Investigating natural compounds and nanoparticles for their anti-cancer potential is an active area of research.
Purpose of the Study:
- To evaluate the efficacy of nano tamoxifen, nano yeast, nano isoflavone, and nano silymarin in preventing breast cancer progression.
- To assess the impact of these nano-formulations on key biomarkers of cancer development and progression in an experimental model.
Main Methods:
- Induction of breast cancer in female Sprague-Dawley rats using 7,12-dimethylbenz[a]anthracene (DMBA).
- Administration of nano tamoxifen, nano yeast, nano isoflavone, and nano silymarin.
- Analysis of biomarkers including 8-OHdG, apoptosis, ErbB-2, lipid peroxide, and total antioxidant levels.
Main Results:
- Nano yeast and nano silymarin significantly elevated 8-OHdG levels, indicating oxidative stress.
- Nano tamoxifen significantly reduced 8-OHdG levels.
- Nano silymarin significantly increased apoptosis, while nano isoflavone showed a significant reduction.
- Nano tamoxifen elevated ErbB-2 levels, whereas nano silymarin and nano isoflavone reduced them.
- Nano isoflavone significantly reduced lipid peroxide levels.
- Nano silymarin demonstrated a significant reduction in total antioxidant capacity.
Conclusions:
- Nano formulations of tamoxifen, isoflavone, and silymarin show potential in modulating breast cancer progression markers.
- Nano silymarin and nano isoflavone exhibit promising anti-cancer effects through apoptosis induction and oxidative stress reduction.
- Further research is warranted to explore these nano-compounds as a novel strategy for breast cancer resistance and prevention.
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