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Related Experiment Video

Updated: Feb 23, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Thyroid storm and warm autoimmune hemolytic anemia.

Joseph A Moore¹, Louise Gliga¹, Srikanth Nagalla²

¹Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, United States.

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis

|September 6, 2017

Summary

This case study highlights a rare instance of a young woman experiencing both thyroid storm and autoimmune hemolytic anemia (AIHA) simultaneously. Prompt treatment led to full recovery, emphasizing the importance of recognizing these concurrent autoimmune conditions.

Keywords:

Graves disease Thyroid storm Thyrotoxicosis Warm autoimmune hemolytic anemia

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Area of Science:

Endocrinology
Hematology
Immunology

Background:

Graves' disease, a common cause of hyperthyroidism, can be associated with other autoimmune conditions.
Autoimmune hemolytic anemia (AIHA) is a rare but serious complication that can occur alongside Graves' disease.

Observation:

A young female patient presented with symptoms of thyroid storm, including altered mental status, nausea, vomiting, and diarrhea.
Laboratory results indicated severe anemia (hemoglobin 3.9g/dL) with signs of hemolysis (low haptoglobin, reticulocytosis, positive direct antiglobulin test) and hyperthyroidism (low TSH, high FT4).

Findings:

The patient was diagnosed with concurrent thyroid storm and warm autoimmune hemolytic anemia.
Treatment involved glucocorticoids, antithyroid medications, propranolol, folic acid, and blood transfusion, leading to complete resolution of both conditions within one month.

Implications:

This case underscores the potential for concurrent autoimmune disorders in patients with Graves' disease.
Recognizing and managing thyroid storm and AIHA together is crucial for effective patient outcomes.
Hyperthyroidism can impact hematopoiesis, and anemia is a notable complication in thyrotoxicosis.