Related Experiment Video
Updated: Feb 23, 2026

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
Published on: June 27, 2020
Emerging Insights into the Roles of the Paf1 Complex in Gene Regulation
S Branden Van Oss1, Christine E Cucinotta1, Karen M Arndt1
1Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Abstract:
The conserved, multifunctional Polymerase-Associated Factor 1 complex (Paf1C) regulates all stages of the RNA polymerase (Pol) II transcription cycle. In this review, we examine a diverse set of recent studies from various organisms that build on foundational studies in budding yeast. These studies identify new roles for Paf1C in the control of gene expression and the regulation of chromatin structure. In exploring these advances, we find that various functions of Paf1C, such as the regulation of promoter-proximal pausing and development in higher eukaryotes, are complex and context dependent. As more becomes known about the role of Paf1C in human disease, interest in the molecular mechanisms underpinning Paf1C function will continue to increase.
More Related Videos
Related Concept Videos
Combinatorial Gene Control
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
Master Transcription Regulators
RNA Polymerase II Accessory Proteins
Co-activators and Co-repressors
Co-activators and Co-repressors
Prokaryotic Transcriptional Activators and Repressors
Transcription of prokaryotic...

