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  11. Inhibition Of Il-17-committed T Cells In A Murine Psoriasis Model By A Vitamin D Analogue.

Inhibition of IL-17-committed T cells in a murine psoriasis model by a vitamin D analogue.

Nobuhiro Kusuba1, Akihiko Kitoh1, Teruki Dainichi1

  • 1Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

The Journal of Allergy and Clinical Immunology
|September 6, 2017

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View abstract on PubMed

Summary
This summary is machine-generated.

Topical calcipotriol (CAL) effectively treats psoriasis-like skin conditions by reducing T helper 17 (T17) cell accumulation in treated and distant lesions. This vitamin D analogue demonstrates a dual action, impacting both local and remote inflammatory sites.

Area of Science:

  • Dermatology
  • Immunology
  • Pharmacology

Background:

  • Understanding the mechanism of topical vitamin D analogues in psoriasis treatment is crucial.
  • Psoriasis pathogenesis involves IL-17A, a key cytokine in T helper 17 (T17) cell responses.

Purpose of the Study:

  • To investigate how calcipotriol (CAL), a topical vitamin D analogue, modulates IL-17A-driven psoriasis-like dermatitis in a mouse model.
  • To clarify the in vivo effects of CAL on T17 cell accumulation and related cytokine expression.

Main Methods:

  • Psoriasis-like dermatitis was induced using imiquimod (IMQ) on murine ears.
  • Mice received daily topical CAL treatment before IMQ application.
  • IL-17A-committed T (T17) cell accumulation and cytokine expression (IL-12b, IL-23a) were analyzed.
Keywords:
IL-17AIL-23Psoriasiscalcipotriol

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Main Results:

  • Topical CAL significantly reduced IMQ-induced dermatitis severity and T17 cell infiltration.
  • CAL application abrogated IMQ-induced IL-12b and IL-23a upregulation in the epidermis.
  • CAL inhibited T17 cell expansion in draining lymph nodes and ameliorated dermatitis in distant, untreated skin sites.

Conclusions:

  • Topical calcipotriol exerts therapeutic effects on psoriasis by reducing T17 cell accumulation in both treated and distant lesions.
  • CAL's mechanism involves suppressing IL-23 production by Langerhans cells and inhibiting T17 cell expansion.
  • The findings highlight CAL's potential for treating localized and potentially systemic psoriatic inflammation.
imiquimod
vitamin D analogue