Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioactivation and Tissue Toxicity01:25

Bioactivation and Tissue Toxicity

38
Bioactivation is a metabolic process that transforms less reactive substances into highly reactive metabolites, initiating tissue toxicity. This transformation can lead to various toxic effects, including carcinogenesis and teratogenesis. Reactive metabolites are classified into two main types: electrophiles and free radicals.Electrophiles are electron-deficient species and are produced primarily by the enzyme cytochrome P-450 during the metabolism of compounds containing carbon, nitrogen, or...
38
Toxic Reactions: Overview01:26

Toxic Reactions: Overview

2.6K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
2.6K
Drug toxicity: Idiosyncratic Reactions01:16

Drug toxicity: Idiosyncratic Reactions

50
Idiosyncratic drug reactions represent abnormal chemical responses that vary significantly among individuals, ranging from extreme sensitivity to low doses to insensitivity to high doses. These reactions often occur due to the drug's covalent binding with serum proteins, forming a foreign hapten that triggers an immunotoxicological response. The variability in drug reactions has a strong pharmacogenetic foundation, with genetic differences crucial in how individuals metabolize drugs. For...
50

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Provocation of occupational asthma by non-specific irritation and its relevance for the classification of chemicals as respiratory allergens: a case study of methyl methacrylate.

Regulatory toxicology and pharmacology : RTP·2026
Same author

Derivation of a Point of Departure using NAMs for application in Quantitative Risk Assessment of fragrance materials.

Regulatory toxicology and pharmacology : RTP·2026
Same author

Occupational asthma: dust exposure as a contributory factor and implications for classification of respiratory sensitisers.

Regulatory toxicology and pharmacology : RTP·2025
Same author

An extended Reference Chemical Potency List (RCPL) for characterising the performance of New Approach Methodologies (NAMs) in measuring the skin sensitisation potency of fragrance chemicals.

Regulatory toxicology and pharmacology : RTP·2025
Same author

Accurate regulatory classification of chemical respiratory allergens: The case for robust characterisation of causation.

Regulatory toxicology and pharmacology : RTP·2025
Same author

Comment regarding: 'On the solubility of azodicarbonamide in water/DMSO mixtures: an experimental and computational study' (2024), by Macetti <i>et al.</i>

Royal Society open science·2024
Same journal

The NTP Chronic Inhalation Study Does Not Support an Inherent Lung Cancer Hazard of Talc: Implications of Lung Particle Overload and Maximum Tolerated Dose.

Regulatory toxicology and pharmacology : RTP·2026
Same journal

Consideration of Carcinogenicity and Mode of Action Information by an Independent Expert Panel to Support Derivation of No-Significant-Risk-Level Values for Vinyl Acetate Monomer.

Regulatory toxicology and pharmacology : RTP·2026
Same journal

Which carcinogenicity study should I use? Automated identification of reliable studies.

Regulatory toxicology and pharmacology : RTP·2026
Same journal

Adoption of artificial intelligence in drug review across the lifecycle: Transformation of regulatory decision-making.

Regulatory toxicology and pharmacology : RTP·2026
Same journal

Cardiovascular outcomes following intrauterine and lactational exposure to cyantraniliprole in male Wistar rats.

Regulatory toxicology and pharmacology : RTP·2026
Same journal

Pesticide residue and mycotoxin occurrence in apples and their impact on human health in Morocco.

Regulatory toxicology and pharmacology : RTP·2026
See all related articles

Related Experiment Video

Updated: Feb 23, 2026

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
07:08

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

6.7K

Bisphenol A and immunotoxic potential: A commentary.

Ian Kimber1

  • 1Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.

Regulatory Toxicology and Pharmacology : RTP
|September 6, 2017
PubMed
Summary
This summary is machine-generated.

Current research indicates no strong evidence that Bisphenol A (BPA) significantly harms the immune system. Studies reviewed show inconsistent data, suggesting BPA is unlikely to cause immunotoxicity or related health issues.

Keywords:
AllergyBisphenol AImmunological toleranceImmunotoxicity

More Related Videos

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays
08:28

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Published on: April 26, 2018

6.5K
Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

13.4K

Related Experiment Videos

Last Updated: Feb 23, 2026

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
07:08

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

6.7K
Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays
08:28

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Published on: April 26, 2018

6.5K
Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

13.4K

Area of Science:

  • Environmental toxicology
  • Immunology
  • Public health

Background:

  • Bisphenol A (BPA) is a chemical used in polycarbonate and epoxy resins.
  • Concerns exist regarding BPA's potential immunotoxic effects on human health.
  • Previous reviews by the European Food Safety Authority (EFSA) have assessed BPA safety.

Purpose of the Study:

  • To critically review data on BPA's ability to affect the immune system, including during development.
  • To evaluate BPA's potential to cause respiratory allergies, airway inflammation, and compromise tolerance to dietary proteins.
  • To complement existing EFSA evaluations on BPA's immunotoxicity.

Main Methods:

  • Review of human observational and cross-sectional studies.
  • Analysis of experimental animal investigations.
  • Inclusion of in vitro study findings.

Main Results:

  • The reviewed data on BPA's immunotoxic potential are often contradictory and inconsistent.
  • Limitations in experimental design were noted in several investigations.
  • No persuasive evidence was found to support significant immunotoxic effects of BPA.

Conclusions:

  • Currently, there is no clear or convincing evidence that Bisphenol A causes immunotoxicity.
  • The available data suggest BPA does not pose a significant risk for adverse health effects related to immune system impairment.
  • Further investigation may be needed to address inconsistencies in existing research regarding BPA and immune function.